On 15 December 2016, they announced that Pennetta was pregnant with their first child.
At the China Open, she made the quarterfinal, losing to Zvonareva, 5—7 in the third set.
In the she notched up two top-20 wins over Sam Stosur and Li Na, before losing to unseeded Aravane Rezaï in the quarterfinals.
Pennetta lost in the third round of the Sony Ericsson Open in Key Biscayne, another Premier Mandatory event, to Mauresmo.
Pennetta was the thirteenth seed at the Australian Open, where she lost in the third round to Anabel Medina Garrigues.
In the she was crushed by eventual champion 6—0, 6—1.
In the she was upset by German in the first round.
In the second round, she double-bageled Sania Mirza 6—0, 6—0.